Purpose.This trial aimed to compare mortality and recovery of renal function in acute kidney injury (AKI) patients treated with\ndifferent durations of prolonged hemodialysis (PHD) sessions (6 h versus 10 h). Methodology. We included patients with sepsisassociated\nAKI, >18 years, who are in use of a norepinephrine (lower than 0.7 ucg/kg/min). Results. One hundred and ninety-four\npatients were treated with 531 sessions of PHD (G1=104 and G2=90 patients).The two groups were similar in age and SOFA.There\nwas no significant difference in hypotension, hypokalemia, and anticoagulation during PHD sessions. The two groups showed\ndifferences in filter clotting, hypophosphatemia, and treatment discontinuation (12.3 versus 23.1%, p=0.002; 15.5 versus 25.8%,\np=0.005; and 7.9 versus 15.6%, p=0.008, respectively). There was no difference in fluid balance (FB) before and after PHD sessions.\nDeath and complete recovery of renal function were similar (81.3 versus 82.2%, p=0.87 and 21 versus 31.2%, p=0.7, respectively). At\nlogistic regression, the positive FB before and after dialysis was identified as risk factor for death, while volume overload after three\nPHD sessions and predialysis creatinine were negatively associated with recovery of renal function in 28 days. Conclusion. There\nwas no difference in the mortality and recovery of renal function of AKI patients submitted to different durations of PHD and\nsessions lasting 10 h presented higher filter clotting, hypophosphatemia, and treatment discontinuation. ISRCTN Registry number\nis ISRCTN33774458.
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